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Blood Filtration And Separation Materials Become New Research Topics

2011/12/26 9:22:00 20

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New Research Topics On Blood Filtration And Separation Materials

With the progress of modern medicine, more and more countries in the world choose to import blood components instead of whole blood in blood pfusion, which can reduce the allergic reaction of patients and improve the utilization efficiency of different components of blood.

In Russia, the application of blood component pfusion is still in its early stage.

stage

It only accounts for 5% of the total blood pfusion, but there is a huge market potential. Therefore, studying blood components filtration and separation materials has become a new one.

scientific research

Topic.

Russian Meishan gum

chemical fiber

In the center of scientific research, leukocyte filtration and separation materials in blood were studied.

It is reported that the white blood cells needed to be filtered in the blood are 7~15 micron in diameter, and some particles are 20 microns in diameter. Other blood components such as red blood cells and platelets are 2~7 microns in diameter.

Therefore, the components of blood components should have the following characteristics: suitable pore size, necessary permeability, good hydrophilicity, adequate negative charge on the surface of the filter material, which can help white blood cells be filtered through the corresponding filter holes; when filtering, the media can not be adhered to the filter material; and the filter material has less mechanical damage to red blood cells and platelets in the blood.

Internationally, nonwoven materials such as needling, spunlacing, hot-melt, paper making, and electrospinning are commonly used in white blood cell filter materials. They contain polyamide fiber, polyester fiber, viscose fiber and so on. They all have a certain negative charge.

During filtration, the filtration state is closely related to the size of the filter hole and the bulking degree of the filter material.

The surface density and critical surface penetration of the filter determine the amount of filtration, and whether the particulate matter in the blood will be attached to the filter material. In order to ensure that the particles in the blood pass through the corresponding filter holes, the surface of all fibers should be no less than 10 MV potential, and the filter material that is not up to the required requirements should be specially disposed.

Russia's white cell filter material, viscose filament yarn, bleached cellulose added with sulphate, and papermaking nonwovens can be used effectively, but the retrofitting cost of paper-making equipment is high. Under general production conditions, the production of different filter materials and the calculation of ergonomics are complex.

Russia also has non-woven filter materials produced by water needling.

The white blood cell filter material of the well-known Pall company in the international field is arranged in 3 different specifications: 20~33 micron, 7~15 micron, and 3~5 micron.

The pore size decreases.

Russian filter material has only one specification.

(see table)

The data in the table show that the total pore volume of Pall filter material is 76.4%, which is lower than the technical requirements, while the surface density of Russian filter material is higher than that of the technical requirements.

The white blood cell filtration device consists of three parts. The first part is polyester fiber (hydrophilic modified) single-layer nonwoven material, which mainly filters out the larger substances and blood clots in the blood.

The second part is viscose fiber and polyester fiber, hydropuncture (or needle method) of non-woven filter material, filtration and separation of white blood cells and other components of blood, the third part is fine filtration, using polyamide ultrafine fiber, diameter 2~3 microns, electrospun non-woven material, because the static electrospinning fiber distribution is very uniform, the filter hole size adjustment is relatively easy.

After analyzing and comparing the data of Russian and foreign white blood cell filter materials, the scientific research center of viscose and viscose fiber in Russia has selected the three parts of the filtration device.

According to the principle that the smaller the fiber is, the larger the material surface area is and the greater the total capacity of the filter hole, the polyamide ultrafine fiber is selected. The diameter is 2~3 micron, and the electrospinning is made of fine filtrate white cell filter material. The average pore diameter of the filter hole is 6 microns, the maximum pore diameter is 7.2 microns, and the total porosity is 92%.

On the Russian blood filtration device, the distilled water was filtered through a single layer polyamide fiber electrostatic spinning filter. The filtration volume was 103~105 ml / min. After the filter was filled into the filter part, the filtration volume was 92~96 ml / min.

The center and the Moscow national blood replacement and medical preparation Institute and other units, according to the Russian national standard, have carried out chemical safety tests for medical products, including toxicology testing and blood composition changes after filtration.

It is reported that the research project is one of the research projects planned by the Russian Belarus alliance.