During The Anti Epidemic Campaign In Guangzhou: The Transmission Track Of The Virus Was Basically Delineated, And 100000 Doses Of "One Shot Of New Crown Vaccine" Rushed To Aid

Guangzhou is in the process of anti epidemic.

On May 30, Haizhu District and Yuexiu District of Guangzhou City successively issued the notification of all staff nucleic acid detection, and the scope of notification was expanded again. Guangdong medical staff were continuously sent to support many places. On May 31, Tianhe part of the region also began to enter the stage of full-scale screening.

Most of the cases in Guangzhou were asymptomatic and mild. However, the characteristics of the spread of the epidemic is very prominent, experts believe that the virus in the epidemic spread very fast and has strong transmission power.

At a press conference in Guangzhou on May 31, liming, vice mayor of Guangzhou Municipal People's government, said that since Guangzhou started mass vaccination of new coronavirus vaccine in March this year, by 16:00 on May 31, the city had received 13.136 million doses of vaccine, 10.111 million people, and 3.2522 million people in the city had completed the whole course of immunization. And basically determine the new coronavirus transmission trajectory, and in control. As of 14:00 on May 31, 11 positive cases had been found in Guangzhou.

On May 30, 2021, Guangzhou, residents queue up for nucleic acid detection at Xu's house in Gaodi street. Photo by Zheng dikun

Fish with multiple nucleic acid detection as leak proof net

In the city's large-scale screening of nucleic acid, many communities and regions require multiple nucleic acid detection.

According to the latest report, a total of 1782 nucleic acid sampling sites were set up in Guangzhou, 7075 medical staff were invested, and nearly 500 on-site nucleic acid detection teams were deployed, with a daily collection capacity of more than 1.5 million person times, so as to fully guarantee the large-scale nucleic acid screening in relevant regions.

In view of the deployment of multiple nucleic acid detection, Guo yabing, executive deputy director of the center for infectious diseases and liver diseases of Southern Hospital of Southern Medical University, told reporters of 21st century economic news: "the results of PCR detection are related to virus mutation (the mutation of key points of primers may cause false negative). It is inevitable that there will be missed fish in the general screening, but with the isolation in the community and the screening before the isolation is removed, there are few fish escaping from the net. "

In addition, some people in the nucleic acid testing industry told the reporter of the 21st century economic report that "the state has a set of standards for judging positive. At present, if it is suspicious, it is necessary to use at least two kits to verify the positive, because the sensitivity of the kits between companies will be different. For example, if company a tests positive, it must be tested again by company B, So you'll see that you need to measure the nucleic acid several times before you report a diagnosis. "

What is sensitivity and specificity? Sensitivity is the true positive rate, that is, the probability of accurately detecting the corresponding patients; Specificity is the true negative rate, which means the probability of correctly excluding the detected person carrying the corresponding virus.

In fact, for the detection kit, high sensitivity and high specificity can not be both: high sensitivity means low specificity, high specificity means low sensitivity.

With the improvement of the sensitivity of detection reagents, the missed diagnosis rate will decrease, but the misdiagnosis rate will increase. In other words, highly sensitive detection methods can more accurately identify patients with detected diseases, but also more likely to be misdiagnosed. The purpose of multiple nucleic acid detection is to avoid the occurrence of missed fish.

Zhang zhoubin, deputy director of the center for Disease Control and prevention of Guangzhou, said that at present, the challenge facing Guangzhou is unprecedented, because the new coronavirus R0 (basic infection number: the average number of people infected with a certain infectious disease will transmit the disease to other individuals) has been continuously high, reaching 5 on the 26th, reaching the highest value of 6.06 on the 29th, and falling to 4.19 on the 30th. However, according to previous public reports, most of the R0 of the new coronavirus is between 2-3.2, which shows that the transmission of the epidemic in Guangzhou is strong and the challenge is great.

Zhang zhoubin also pointed out that at present, R0 is declining continuously, which also means that the prevention and control measures are effective. If we observe it for a few days, we will see good results. At present, we need to rationally treat the new cases in recent days. At present, the new cases are all within the warning circle of classified management and control.

In terms of the city's material supply, liming said: "we will spare no effort to provide living security services for the affected areas and all citizens. The city's 543 meat and vegetable markets and chain supermarkets guarantee the normal operation of 1200 stores of supply enterprises. Large backbone business enterprises and e-commerce platforms prepare goods in the supply chain five times higher than usual, increase the frequency of replenishment, and make concerted efforts online and offline. "

Re deployment of vaccination

In addition, from 17:00 on May 31, Guangzhou suspended the social vaccination of the new crown vaccine.

"In doing so, we have the following considerations." "The first is to concentrate medical and health care forces to carry out large-scale nucleic acid screening," Liming said. At present, Guangzhou needs to mobilize all levels of medical institutions to devote themselves to nucleic acid screening, medical observation of sampling and isolation, and health monitoring of residents. Second, the general public's willingness to vaccinate has been rising recently, and vaccination sites in the streets are overcrowded. In order to reduce the risk of possible new coronavirus infection, social vaccination was temporarily suspended. We will restart the work of personal appointment vaccination and on-site vaccination as soon as possible according to the situation of prevention and control. "

At 0:30 am on May 31, a cold chain truck carrying 100000 doses of new coronavirus vaccine arrived at the Guangdong Provincial Center for Disease Control and prevention in Panyu, Guangzhou, after a long journey of more than 2000 kilometers.

It is reported that this batch of "one shot of new coronavirus vaccine" is a recombinant new coronavirus vaccine (Ad5 ncov) developed by kangxinuo biological Co., Ltd. and Chen Wei team of Bioengineering Institute, Military Medical Research Institute, Academy of Military Sciences. The Guangdong Provincial Center for Disease Control and prevention will launch it to the corresponding areas for use from now on.

According to the relevant person in charge of kangxinuo biological Co., Ltd., the 100000 doses of vaccine urgently deployed by the company to support Guangdong Province is kweisa produced by kangxinuo biological Tianjin factory, which is the first domestic adenovirus vector new crown vaccine approved. "The biggest feature of this vaccine is that it can produce effective protection after 14 days of single injection, and the overall protection effect for all symptoms is 68.83%, It exceeds the 50% requirement of the World Health Organization, and its protective effect on severe cases is 95.47%, which is especially suitable for emergency use

According to epidemic prevention experts from the Guangdong Provincial Center for Disease Control and prevention, the vaccination procedure of each vaccine is determined by the technical route of the vaccine. Strict clinical trials are required to verify the safety and effectiveness of each vaccine before it can be put on the market.

According to the vaccination situation in other provinces, the safety and effectiveness of one dose and two doses of vaccine are similar. Previously, the two kinds of inactivated vaccines used in Guangdong Province were both two injections. The arrival of the new coronavirus vaccine with one dose provides an additional scheme for the vaccination of new coronavirus vaccine in Guangdong Province, This time, 100000 doses of new crown vaccine will be put into the corresponding areas of the province according to the needs of epidemic prevention and control.

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